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Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology, by Bernhard Rupp
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Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.
Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.
- Sales Rank: #560689 in Books
- Brand: Brand: Garland Science
- Published on: 2009-10-20
- Original language: English
- Number of items: 1
- Dimensions: 10.80" h x 1.50" w x 8.50" l, 4.15 pounds
- Binding: Hardcover
- 800 pages
Features
- Used Book in Good Condition
Review
PRAISE FOR Biomolecular Crystallography:
"Over the past 34 years Louise and I have often discussed the possibility of updating [Protein Crystallography]....However, this marvelous text by Bernhard Rupp provides everything that we could have done and more: indeed all that is required for the student of 2010. Biomolecular Crystallography is an impressive volume. Its 808 pages are beautifully written and wonderfully illustrated, many in colour....This book will be an essential part of the library of any department that claims to make contributions to modern biology....[and] a necessary addition also to the libraries of big pharmaceutical companies and small biotechs. This is a book to be enjoyed by all who wish to become structural biologists. I am also sure that many practicing structural biologists - even some who consider themselves mature - would do well to read its pages." - Tom Blundell, Journal of Applied Crystallography
"It is a masterpiece. It is the book which the MX community has been waiting for and it is an absolute must-have for everybody in the field." - Acta Crystallographica
"This is the book that molecular biologists and the crystallographic community have been waiting for." - Alexander McPherson, University of California at Irvine, USA
'Biomolecular Crystallography is first and foremost a comprehensive reference text and laboratory manual for the practicing structural biologist, from the basics of biomolecular structure to modern advanced and powerful techniques in biomolecular structure determination, and analysis and application of structural information. Figures and graphs computed from new and original data are used extensively to help clarify important concepts, and derivations of all relevant mathematical and statistical principles―many of which have never been brought together in a single volume―are presented. This fulfils a long-felt need!' - Ian J. Tickle, Astex Therapeutics, Cambridge, UK
'This thorough treatment of modern macromolecular X-ray crystallography combines a comprehensive coverage of the fundamentals with methodological details that are often omitted in introductory texts. It will be of value to anyone that works in macromolecular X-ray crystallography, particularly to graduate students or postdoctoral fellows who are mastering the technique.' - Mark Wilson, University of Nebraska, USA
'Given the extraordinary progress in biomolecular crystallography, the challenge of providing a comprehensive and authoritative overview, starting from first principles, is formidable. Dr Rupp has, however, succeeded admirably.' - Brian Matthews, University of Oregon, USA
From the Author
For those who complained about the weight - it is here now: Corrected second e-printing/Kindle edition includes all corrections from the errata page up to mid-2012 - pls see BMC errata page on my web site for details.
Best wishes for your crystallography studies,
BR
About the Author
Bernhard Rupp is the CEO and founder of q.e.d. life science discoveries in California. Dr. Rupp established the protein drug target crystallography group at the University of California Lawrence Livermore National Laboratory in 1993 and expanded it into high throughput crystallization and structural genomics with focus on drug target structures and structure guided drug discovery. He was also a founding member of TB Structural Genomics Consortium. Dr. Rupp is a consultant for several US biotech ventures, universities, and instrument manufacturers. He is a member of the U.S. National Academy of Sciences Committee for Crystallography and NAS Keck Futures Initiatives panel. Dr. Rupp lectures regularly at NSF sponsored workshops on Biomolecular Crystallography and at the EMBO PEPC workshops on protein expression,
Most helpful customer reviews
6 of 6 people found the following review helpful.
A model text encompassing aspects of practical and mathematical crystallography
By Eric Wade Reinheimer
Macromolecular structure determination, which encompasses crystallographic pursuits undertaken from the mid-1930s to the present, has yielded scientific discoveries often considered to be the cornerstone upon which our understanding of the fundamentals of life can be built. As the technology and information renaissance has evolved, the spotlight has been cast upon the need for a deeper understanding of the mysteries locked within the structure of macromolecular systems and for knowledgeable and astute practitioners of diffraction science whom hold the keys to unlock those secrets. In order to properly train the next generation of structural biologists educated in crystallography, it is essential to have a modern reference volume which deftly unites the various topics critical to this field of science. Such a need has been addressed by Biomolecular Crystallography, which not only focuses on the key elements essential for any crystallographic textbook, such as crystal growth, the physics of diffraction, symmetry, the phase problem, model building, refinement and validation, but also includes information useful for the practicing structural biologist, such as protein production and engineering, bioinformatics and structure-based drug design.
As a crystallographer myself, I was especially intrigued by the organization of the volume which is reminiscent of a crystallographic structural determination. The books thirteen chapters, further arranged into five parts, cover various topics as one proceeds from a protein sequence to a crystal, the fundamentals of protein crystallography, data collection, structure determination and interpreting your structure. In all chapters, the educational value of this text is further enforced by boxes which highlight important concepts which are collected in a separate section at the conclusion of each chapter. Glossary terms are highlighted in blue in the body of the text and well defined at the close of the book. If the student or seasoned crystallographer perusing the volume wishes to undertake further reading and informational discovery, all references used to formulate each book chapter's key concepts are offered at each chapter's close. Flowcharts, numerous in the book, provide excellent reinforcement of the iterative processes encountered by the practicing macromolecular crystallographer. All figures within the book are aesthetically appealing and function well in illustrating concepts and augmenting points made by the author.
Throughout the text, I found that the mathematical development offered by Dr. Rupp was not lacking and was in fact superior to those offered in other crystallographic textbooks I have surveyed. By his own volition, he states that there are over 600 mathematical equations offered within the book and that their inclusion can serve to explain fundamental concepts that may require additional pages to outline. In order to assist readers with the explanation of essential mathematical concepts and tender a means to gain an appreciation of the mathematics of crystallography, within the Appendix is included a section on mathematical basics and tools which both the layperson and seasoned master may find practical. Furthermore, Biomolecular Crystallography offers a great discussion, both mathematical and in prose, on how to address and overcome the phase problem. I have had the opportunity to listen to Dr. Rupp lecture on this topic specifically and his explanations on the phase problem and how to conquer it are clear and concise and serve to allay any misunderstanding of it; his description in the book echoes the concepts he describes in a lecture and is equivalent in its lucidity.
Whether someone is an expert or novice, the concepts governing macromolecular structure determination presented in Biomolecular Crystallography can serve as a tutorial to train the next generation of scientists interested in elucidating the structures of new large, high molecular weight molecules. The book does not try to avoid the concept that such a structure determination is an intricate process; however, it provides avenues to overcome these concerns and endeavors to instruct those interested in the field on methodologies and avenues to become adroit artisans of macromolecular X-ray crystallography. It is a textbook and a compendium of information to which I offer my supreme recommendation.
2 of 2 people found the following review helpful.
the best overall review of crystallography you can find
By C. L. Allen
As a budding crystallographer reading every book i could put my hands on in preparation for my dissertation and PhD defense, this was the best book I found by leaps and bounds. Now I'm at a research institute that specializes in crystallography and it is the text for their classes.
3 of 4 people found the following review helpful.
Good balance between theory and physical concepts
By Sandipan Chowdhury
I had been looking for a good book on crystallography of proteins for a long time. I had looked into Jan Drenth's book - but found it to be too superficial and at best, only a run through guide for last minute preparation for exams. This book is definitely a great one for those who want to understand protein crystallography real well - adequate and clear explanations, quite detailed and thorough and definitely written for a very broad audience. My only complaint is that it is not very heavy on the fundamentals of X-ray diffraction and phase problem analysis. While descriptions might seem to be adequate initially, the math is quite lacking. But then again, I've not yet found good biomolecular crystallography books which explain the physics of the problem any better. I had to opt for a mineral/small molecule crystallography book (by Giacovazzo Fundamentals of Crystallography) for frequent reference and when used together - they seemed to very good and rigorous. Nonetheless I would strongly reccommend this book - probably its the best in the market (related to biomolecules).
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